DisodiuM Tiludronate

DisodiuM Tiludronate - Names and Identifiers

Name	TILUDRONIC ACID, DISODIUM SALT
Synonyms	SKELID SR-41319B Unii-bh6m93cia0 DisodiuM Tiludronate TILUDRONIC ACID, DISODIUM SALT Disodium (4-chlorophenylthio)methylenediphosphonate [[(4-CHLOROPHENYL)THIO]METHYLENE]BIPHOSPHONIC ACID, DISODIUM SALT disodium {[(4-chlorophenyl)sulfanyl]methanediyl}bis[hydrogen (phosphonate)] [[(4-Chlorophenyl)thio]methylene]biphosphonicAcid,DisodiumSalt,SR-41319B,Skelid
CAS	149845-07-8
InChI	InChI=1/C7H9ClO6P2S.2Na/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14;;/h1-4,7H,(H2,9,10,11)(H2,12,13,14);;/q;2*+1/p-2

DisodiuM Tiludronate - Physico-chemical Properties

Molecular Formula	C7H7ClNa2O6P2S
Molar Mass	362.57
Melting Point	>300°C
Boling Point	600.7°C at 760 mmHg
Flash Point	317.1°C
Solubility	Methanol (Slightly), Water (Slightly)
Vapor Presure	2.79E-15mmHg at 25°C
Appearance	Solid
Color	White to Off-White
Merck	14,9441
Storage Condition	-20°C Freezer
In vitro study	The ability of Tiludronate to inhibit proton transport is 5-fold higher in kidney-derived vesicles (IC 50 =1.1 mM) and 10,000-fold higher in vesicles derived from osteoclasts (IC 50 =466 nM). Tiludronate also potently inhibits proton transport in yeast microsomal preparations (IC 50 =3.5 microM) and inhibits the activity of purified yeast V-ATPase. The inhibition of the osteoclast V-ATPase-mediated proton transport by Tiludronate is rapid, pH-dependent, and reversible.
In vivo study	Tiludronate exerts a dose-dependent inhibitory activity on bone resorption. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. Tiludronate is also tested in other models of osteoporosis. In the castrated male rat model, Tiludronate (5-200 mg/kg; p.o.) prevents the decrease in the skeletal mass, assessed physically by measuring the bone weight and density or chemically by determining the calcium and phosphate content.

DisodiuM Tiludronate - Reference Information

biological activity

Tiludronate (Tiludronic Acid) disodium is an oral active bisphosphonate, which can play a role in bone regulation. Tiludronate disodium are used in the study of metabolic bone diseases. Tiludronate disodium is a potent inhibitor of osteoclast vacuolar H (+)-ATPase.

Last Update：2024-04-09 20:44:15